Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP
JD Chrispell, Y Xiong, ER Weiss - Journal of Biological Chemistry, 2022 - ASBMB
In the vertebrate retina, phosphorylation of photoactivated visual pigments in rods and cones
by G protein–coupled receptor kinases (GRKs) is essential for sustained visual function.
Previous in vitro analysis demonstrated that GRK1 and GRK7 are phosphorylated by PKA,
resulting in a reduced capacity to phosphorylate rhodopsin. In vivo observations revealed
that GRK phosphorylation occurs in the dark and is cAMP dependent. In many vertebrates,
including humans and zebrafish, GRK1 is expressed in both rods and cones while GRK7 is …
by G protein–coupled receptor kinases (GRKs) is essential for sustained visual function.
Previous in vitro analysis demonstrated that GRK1 and GRK7 are phosphorylated by PKA,
resulting in a reduced capacity to phosphorylate rhodopsin. In vivo observations revealed
that GRK phosphorylation occurs in the dark and is cAMP dependent. In many vertebrates,
including humans and zebrafish, GRK1 is expressed in both rods and cones while GRK7 is …
